阮慧瞳
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博士，副研究员/硕导，再生医学材料课题组。四川大学华西药学院本科，复旦大学药学院药剂学博士，2019-2021年于上海交通大学医学院/上海市伤骨科研究所从事博士后研究。先后前往美国北卡罗莱纳大学教堂山分校/加州大学洛杉矶分校交流学习。全国“博新计划”、上海市“东方英才计划”、上海市“晨光计划”、上海市超级博士后、交大医学院博士后激励计划入选者。长期致力于骨、神经等相关的智能化药物递送系统策略开发，并主要在响应型微-纳材料、功能化微球设计、内源性修复策略等方面进行研究。已在国际著名学术期刊上发表论文40余篇，包括Nat. Biomed. Eng.，Adv. Mater.，The Innovation等期刊。主持国自然、博士后科学基金、上海市卫健委项目等多项基金。担任J. Nanobiotechnol., Nano Research等国际著名学术期刊审稿人，担任Cell Press旗下综合性英文期刊The Innovation（IF 33.1），The Innovation Medicine青年编委。
一、主持项目：
1. 国自然面上项目，2024-01至2027-12，主持；
2. 上海市“东方英才计划”，2024-01至2026-12，主持；
3. 上海市“晨光计划”，2023-01 至 2024-12，主持；
4. 上海市卫生健康委员会临床科研青年项目，2023-07 至 2026-06，主持；
5. 国自然青年项目，2021-01至2023-12，主持；
6. 国家“博新计划”，2020.01-2021.07，主持；
7. 国家博士后基金面上资助，2019.11-2021.07，主持。
二、代表性成果：
1. Wei Chen#, Dandan Zheng#, Hao Chen#, Tingjun Ye, Zhihong Liu, Jin Qi, Hongxing Shen, Huitong Ruan*, Wenguo Cui*, Lianfu Deng*. Circadian clock regulation via biomaterials for nucleus pulposus. Advanced Materials 2023, 35, 2301037.
2. Dandan Zheng#, Wei Chen#, Tongtong Chen, Xiuyuan Chen, Jing Liang, Hao Chen, Hongxing Shen, Lianfu Deng, Huitong Ruan*, Wenguo Cui*. Hydrogen ion capturing hydrogel microspheres for reversing Inflammaging. Advanced Materials 2024, 36, 2306105.
3. Huitong Ruan#, Yongfang Li#, Cheng Wang, Yixu Jiang, Yulong Han, Yiwei Li, Dandan Zheng, Jing Ye, Gang Chen, Guo-yuan Yang, Lianfu Deng, Ming Guo, Xingcai Zhang*, Yaohui Tang*, Wenguo Cui*. Click Chemistry Extracellular Vesicle/Peptide/Chemokine Nanomissiles for Treating CNS Injuries. Acta Pharmaceutica Sinica B 2023, 13(5):2202-2218.
4. Huitong Ruan#, Yongfang Li#, Dandan Zheng#, Lianfu Deng, Gang Chen*, Xingcai Zhang*, Yaohui Tang*, Wenguo Cui*. Engineered extracellular vesicles for ischemic stroke treatment. The Innovation 2023, 4(2), 100394.
5. Xiaoru Sun#, Huitong Ruan*,#, Qidong Liu, Silu Cao, Qi Jing, Yaru Xu, Lize Xiong*, Wenguo Cui*, Cheng Li*. Targeted regulation of neuroinflammation via nanobiosignaler for repairing the central nerve system injuries. Nano Research 2023, 16(2), 2938-2948.
6. Huitong Ruan#, Quanyin Hu#, Di Wen, Qian Chen, Guojun Chen, Yifei Lu, Jinqiang Wang, Hao Cheng, Weiyue Lu*, Zhen Gu*, A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade. Advanced Materials 2019, 31(17), e1806957.
7. Huitong Ruan, Shengyu Yao, Songli Wang, Ruifeng Wang, Cao Xie, Haiyan Guo, Weiyue Lu*. Stapled RAP12 Peptide Ligand of LRP1 for Micelles-Based Multifunctional Glioma-Targeted Drug Delivery. Chemical Engineering Journal 2021, 403, 126296.
8. Huitong Ruan, Linlin Bu, Quanyin Hu, Hao Cheng, Weiyue Lu*, Zhen Gu*, Strategies of Combination Drug Delivery for Immune Checkpoint Blockades, Advanced Healthcare Materials 2019, 8(4), e1801099.
9. Huitong Ruan#, Zhilan Chai#, Qing Shen, Xishan Chen, Bingxia Su, Cao Xie, Changyou Zhan, Shengyu Yao, Huan Wang, Mingfei Zhang, Man Ying, Weiyue Lu*. A Novel Peptide Ligand RAP12 of LRP1 for Glioma Targeted Drug Delivery. Journal of Controlled Release 2018, 279, 306-315.
10. Zhenyu Zhao#, Huitong Ruan#, Aopan Chen, Wei Xiong, Mingzhu Zhang*, Ming Cai*, and Wenguo Cui*. Genetic engineered ultrasound-triggered injectable hydrogels for promoting bone reconstruction. Research, 2023, 6, 0221.
三、联系方式：
邮箱：ruanhuitong@163.com；ruanhuitong@sjtu.edu.cn
通信地址：上海市黄浦区瑞金二路197号瑞金医院11号楼；
上海市嘉定区双单路599号瑞金械谷科创园2号楼。
ruanhuitong@163.com
ruanhuitong@sjtu.edu.cn
地址：上海市瑞金二路197号 电话：021-64313534
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