徐醒,博士,副研究员。博士毕业于中国科学院上海药物研究所,博士期间致力于抗代谢性疾病创新药物的研究。2015年加入上海市伤骨科研究所工作至今,研究方向为抗骨质疏松症的创新药物以及中药现代化的研究。针对伤骨科常用中药,进行化学物质基础的研究,致力于阐明中草药中化学成分与临床用途之间的关系;在此基础上重点针对骨代谢性疾病,对其中多个天然活性分子进行结构优化和构效关系研究,以期研究和开发基于中药的伤骨科创新药物。近五年以第一作者或共同第一作者的身份共发表学术论文8篇,并参与发表多篇论文。
一、主持项目:
1、国家自然科学基金青年项目, 2018/1-2020/12,主持
2、上海市自然科学基金青年项目,2016/7-2019/6,主持
3、上海市卫健委面上项目,2020/1-2022/12,主持
4、上海市卫生局青年科研项目,2016/01-2018/12,主持
二、发表文章:
1.Wang Jingshuan#, Zhang Jiahui#, Zhang Jingzan, Ning Ruonan, Li Chenchen, Xu Xing*, Jiang Min*, Qiu Wenwei*. Synthesis and Biological Evaluation of Heterocyclic Ring-Fused 20(S)-Protopanaxadiol Derivatives as Potent Antiosteoporosis Agents. J Med Chem. 2023 Sep 14;66(17):11965-11984.
2.Tian, Hao & Jiang, Tao & Yang, Kai & Ning, Ruonan & Wang, Tianqi & Zhou, Qi & Qian, Niandong & Huang, Ping & Guo, Lei & Jiang, Min & Xi, Xiaobing & Xu, Xing & Deng, Lianfu. (2022). α-Asarone Attenuates Osteoclastogenesis and Prevents Against Oestrogen-Deficiency Induced Osteoporosis. Frontiers in Pharmacology. 13. 780590. 10.3389/fphar.2022.780590.
3.Jiang T, Yan W, Kong B, et al. The extract of Trachelospermum jasminoides (Lindl.) Lem. vines inhibits osteoclast differentiation through the NF-κB, MAPK and AKT signaling pathways. Biomed Pharmacother. 2020;129:110341.
4.Zhuochao Liu, Kai Yang, Xueming Yan, Tianqi Wang, Tao Jiang, Qi Zhou, Jin Qi, Niandong Qian, Hanbing Zhou, Bo Chen, Ping Huang, Lei Guo, Xingkai Zhang, Xing Xu*, Min Jiang*, Lianfu Deng.(2019) The effects of Tranylcypromine on osteoclastogenesis in vitro and in vivo. FASEB J., 33: 9828-9841.
5.Min Jiang, Lei Peng, Kai, Yang Tianqi Wang, Xueming Yan, Tao Jiang, Jianrong Xu, Jin Qi, Hanbing Zhou, Niandong Qian, Qi Zhou, Bo Chen, Xing Xu*, Lianfu Deng*, Chunhao Yang*. (2019). Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Receptor Activator of Nuclear Factor-κB (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization., J. Med. Chem., 62, 5370-5381.
6.Min Jiang, Tianqi Wang, Xueming Yan, Zhuochao Liu, Yufei Yan, Kai Yang, Jin Qi, Hanbing Zhou, Niandong Qian, Qi Zhou, Bo Chen, Xing Xu*, Xiaobin Xi*, Chunhao Yang*, Lianfu Deng. (2019). A Novel Rhein Derivative Modulates Bone Formation and Resorption and Ameliorates Estrogen-Dependent Bone Loss., J. Bone Miner. Res., 34, 361-374.
7.Xing Xu#, Xueshu Qi#, Yufei Yan, Jin Qi, Niandong Qian, Lei Guo, Changwei Li, Fei Wang, Ping Huang, Hanbing Zhou, Min Jiang*, Chunhao Yang*, Lianfu Deng. Synthesis and biological evaluation of rhein amides as inhibitors of osteoclast differentiation and bone resorption[J]. European Journal of Medicinal Chemistry, 2016, 123: 769-776.
8.Xing Xu, Xin Xu, Peng Liu, Zhiyuan Zhu, Jing Chen, Hai-an Fu, Lili Chen*, Lihong Hu*, Shen, X.*. Structural Basis for Small Molecule NDB as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor. J. Biol. Chem. 2015, 290:19888-19899
9.Xu, X., Wang, G., Zhou, T., Chen, L., Chen, J.*, Shen, X.*. Novel approaches to drug discovery for the treatment of type 2 diabetes. Expert opinion on drug discovery, 2014, 9(9): 1047-1058.