一、研究方向：
1. 骨细胞的来源、分化和衰老的调控机制
2. 骨细胞的系统生物学。
3. 感觉神经在肌腱愈合过程中的作用。
二、主持项目：
1. 国家自然科学基金面上项目，2021-01至2024-12，55万，主持。
2. 国家自然科学基金青年科学基金项目，2018-01至2020-12，25万，主持。
3. 上海市卫生健康委员会临床科研青年项目，2019-01 至 2021-12，主持。
三、代表论文：
1. Yang Kai，Wang Ming，Zhao Yuzheng，Sun Xuxu，Yang Yi，Li Xian，Zhou Aiwu，ChuHuilin，Zhou Huimin，Xu Jianrong，Wu Mian，Yang Jie*，Yi Jing*.A redox mechanism underlying nucleolar stress sensing by nucleophosmin，Nat Commun，2016，7：13599.
2. Yang Kai, Yang Jie*, Yi Jing* . Nucleolar Stress: hallmarks, sensing mechanism and diseases.Cell Stress. 2018 May 10;2(6):125-140.
3. Chen K, Chen H, Deng L, Yang Kai*, Qi J*. IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix. J Vis Exp. 2023 Nov 13;(201). doi: 10.3791/64507.
4. Zhang Y, Zhang J, Sun Z, Wang H, Ning R, Xu L, Zhao Y, Yang Kai*, Xi X*, Tian J*. MAPK8 and CAPN1 as potential biomarkers of intervertebral disc degeneration overlapping immune infiltration, autophagy, and ceRNA. Front Immunol. 2023 May 30;14:1188774.
5. Zhao Z, Cai Z, Chen A, Cai M, Yang Kai*. Application of metabolomics in osteoporosis research. Front Endocrinol (Lausanne). 2022 Nov 14;13:993253.
6. Zhang Yongxin#, Yang Kai#, Yang Jie., Lao Yimin., Deng Lianfu, Deng Guoying, Yi Jing*, Sun Xuxu*, Wang Qiugen*. SENP3 suppresses osteoclastogenesis by de-conjugating SUMO2/3 from IRF8 in bone marrow-derived monocytes. Cell Rep, 2020.8.30 (6), 1951-1963.e4.
7. Chen Kaizhe#, Zhou Qi#, Kang Hui#, Yan Yufei, Qian Niandong, Li Changwei, Wang Fei, Yang Kai*, Deng Lianfu*, Qi Jin*. High Mineralization Capacity of IDG-SW3 Cells in 3D Collagen Hydrogel for Bone Healing in Estrogen-Deficient Mice. Front Bioeng Biotechnol. 2020 Aug 31;8:864.
8. Guo Changjun#, Yang Kai#, Yan Yufei#, Yan Dongmin, Cheng Yifan, Yan Xuemin, Qian Ninandong, Zhou Qi, Chen Bo, Jiang Ming, Zhou Hanbing, Li Changwei, Wang Fei, Qi Jing*, Xu Xiangyang*, Deng Lianfu*. SF-deferoxamine, a bone-seeking angiogenic drug, prevents bone loss in estrogen-deficient mice. Bone. 2018 Oct 30;120:156-165.
9. Kang Hui#, Yang Kai#, Xiao Lianbo#, Guo Lei., Guo Changjun., Yan Yufei, Qi Jing, Wang Fei, Ryffel B, Li Changwei*, Deng Lianfu*. Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesis via the Interleukin-33-MicroRNA-34a-Notch1 Pathway. Front Immunol. 2017 Oct 16;8:1312.
|
|
