杜亚伟,博士,助理研究员,再生医学材料课题组。2021年毕业于东南大学化学生物与制药工程系(墨尔本大学生物化学与药理学系联合培养),获工学博士学位。2021年进入上海交通大学医学院/上海市伤骨科研究所从事博士后研究。研究领域主要聚焦于药物递送系统,特别是天然药物微纳体系调控炎症微环境。已发表SCI期刊论文47篇,其中以第一/共一作者在Adv Mater、Adv Funct Mater、Bioact Mater、Research、Small 等SCI期刊发表论文20篇(篇均IF>10),H指数19;申请专利20项,其中授权9项。主持国家自然科学基金青年项目、中国博士后科学基金面上项目、上海市卫健委临床研究专项面上项目,入选上海市浦江人才计划、交大医学院博士后激励计划。同时,担任中国民族医药学会方药量效研究分会常务理事、中国人口文化促进会中医药健康科普分会常务委员等社会兼职。
一、研究方向:
(1)基于磷脂缀合物的天然化合物新制剂与骨科应用
(2)基于LNP的巨噬细胞靶向干预策略促组织再生
二、主持项目:
2022/01-2024/12 国家自然科学基金-青年科学基金项目(22105127);主持
2021/03-2023/03中国博士后科学基金面上资助(2022M722137);主持
2021/10-2023/09上海市浦江人才计划项目(21PJD045);主持
2022/01-2024/12上海市卫健委卫生行业临床研究专项面上项目(202140128);主持
三、代表性文章(#共同一作):
1. Y Tang#, Y Du#, J Ye#, L Deng, W Cui*. Intestine-targeted explosive hydrogel microsphere promotes uric acid excretion for gout therapy. Advanced Materials. 2023. 2310492
2. F Huang#, Y Du#, Y Chen#, Z Qiu, Z Wang, Y Fan, Y Shi, Z Li, K Yang*, W Cui*, W Jin*. Cellular membrane engineered nanovesicles as three stage booster to target lesion core. Advanced Materials. 2023. 35(48): 2302801
3. C Li#, Y Du#, T Zhang, H Wang, Z Hou, Y Zhang, W Cui*, W Chen*. “Genetic scissors” CRISPR/Cas9 genome editing cutting-edge biotechnology for bone and cartilage repair. Bioactive Materials. 2023. 22: 254-273
4. F Zhang#, Y Du#, J Zheng, Z Cai, T Ding, P Zhuang, D Yang, F Liao, Y Zhang, W Yang, Y Xiao, W He*, W Cui*, W Guo*. Oral administration of multistage albumin nanomedicine depots (MANDs) for targeted efficient alleviation of chronic inflammatory diseases. Advanced Functional Materials. 2023. 33(9): 2211644.
5. J Li#, R Zhang#, Y Du#, G Liu, Q Zhai, Y Dong, W Cui*, P Jia*, Y Xu*. Osteophilic and dual-regulated alendronate-gene lipoplexes for reversing bone loss. Small. 2023.
6. Y Du#, C Li#, Y Zhang, W Xiong, F Wang, J Wang, Y Zhang, L Deng, X Li*, W Chen*, W Cui*. In situ-activated phospholipid-mimic artemisinin prodrug via injectable hydrogel nano/microsphere for rheumatoid arthritis therapy. Research. 2022. 2022: 0003.
7. Y Du, C Giannangelo, W He, G Shami, W Zhou, T Yang, D Creek, C Dogovski, X Li*, L Tilley*. Dimeric artesunate phosphorylcholine conjugate nano-assemblies as slow-release antimalarials to overcome Kelch 13-mutant artemisinin resistance. Antimicrobial Agents and Chemotherapy. 2022. 66(5): e02065-21.
8. C Li#, Y Du#, H Lv, T Zhang, J Zhang, P Zhuang, W Yang, Y Zhang, J Wang*, W Cui*, W Chen*. Injectable amphipathic artesunate prodrug-hydrogel microsphere as gene/drug nano-microplex for rheumatoid arthritis therapy. Advanced Functional Materials. 2022. 32 (44): 2206261.
9. Y Sun#, Q Zhou#, Y Du#, J Sun, W Bi, W Liu, R Li, X Wu, F Yang, N Li, L Song, W Cui*, Y Yu*. Immune reprogramming engineered injectable microspheres with dual-signals for remodeling osteogenic microenvironment. Small. 2022. 18(36): 2270190.
10. Y Du#, W He#, Q Xia, W Zhou, C Yao, X Li*. Thioether phosphatidylcholine liposomes: a novel ROS-responsive platform for drug delivery. ACS Applied Materials & Interfaces. 2019. 11(41): 37411-37420.
四、联系方式:
ywdu@hotmail.com;yaweidu@sjtu.edu.cn
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